Podcasts

We're joined by Zipline cofounder / CTO, Keenan Wyrobek. Zipline is on a mission to build the world’s first logistics system that serves all people equally via their flee…

Chris and Daniel talk with returning guest, Ramin Mohammadi, about how those seeking to get into AI Engineer/ Data Science jobs are expected to come in a mid level engine…

Why AI needs hard rules (not vibe checks), what Anthropic's acquisition of Bun's creators tells us about the AI takeover, Jonah Glover couldn't get Claude to recreate Spa…

Nick Nisi joins us to dig into the latest trends from this year and how they're impacting his day-to-day coding and Vision Pro wearing. Anthropic's acquisition of Bun, th…

What are the recent advances in the field of quantum computing and high-performance computing? And what Python tools can you use to develop programs that run on quantum c…

It is the end of re:Invent! Simon and Jillian share some updates and also take a moment to reflect on 2025.

What happens when code stops being useful and starts being art? Scott talks with artist and programmer Daniel Temkin about his new book Forty-Four Esolangs, a deep dive i…

Amazon CTO, Werner Vogels, stops by to help us explore his tech predictions for 2026 and beyond. Will companionship be redefined by consumer robots? Will quantum-safe bec…

Simon and Jillian catch you up on the highlights from today's keynote PLUS all the "pre:Invent" announcements that took place prior to the event!

Brought to You By:•⁠ Statsig ⁠ — ⁠ The unified platform for flags, analytics, experiments, and more. •⁠ Linear ⁠ — ⁠ The system for modern product development. —Michelle …

See the full show notes for this episode on the website at talkpython.fm/529

In this episode, Matt Garman's 2025 re:Invent keynote unveils exciting AI advancements, including Amazon Nova to Lite, a cost-effective reasoning model, and Amazon Nova 2…

Chris and Daniel unpack how AI-driven document processing has rapidly evolved well beyond traditional OCR with many technical advances that fly under the radar. They expl…

Imagine facing a problem you can't name, something that feels bigger than any bug you've ever had to fix. How do you debug your own mind when you don't even know what's w…

Maxie Reynolds loves an adventure, especially the kind where she’s breaking into buildings (legally). In this episode, she shares stories from her time as a professional …

Matheus Lima on what makes senior developers actually senior, Tega Brain created a browser extension for avoiding AI slop, Andrew Kelley moves Zig from GitHub to Codeberg…

Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems. Thank you for listening …

See the full show notes for this episode on the website at talkpython.fm/528

Our old friend Lars Wikman returns to the show to discuss Linux distro hopping, Elixir, Nerves, embedded systems, home automation with Home Assistant, karate, and more.

Scott sits down with Camille Tomlin, Head of IT at Philadelphia International Airport, to explore the intersection of aviation, technology, and leadership. They discuss h…

Vibe coding was, remarkably, named word of the year by the Collins English Dictionary at the start of November 2025 — pretty good going for a term that was only coined in…

This episode is a special crossover between the Practical AI podcast and The Changelog podcast. Chris was recently invited by longtime friends Jerod Santo and Adam Stacov…

Brought to You By:•⁠ Statsig ⁠ — ⁠ The unified platform for flags, analytics, experiments, and more. Statsig are helping make the first-ever Pragmatic Summit a reality. J…

Discover how AWS leverages automated reasoning to enhance AI safety, trustworthiness, and decision-making. Byron Cook (Vice President and Distinguished Scientist) explain…

What are the steps to get started building a FastAPI application? What are the different types of concurrency available in Python? Christopher Trudeau is back on the show…

In a world of Rust, Go, and Python, why does C++ still matter? Dr. Gabriel Dos Reis joins Scott to explain how C++ continues to shape everything from GPUs and browsers to…

Fireflies CEO, Krish Ramineni shares how the company is transforming AI-powered note-taking into a deeper layer of knowledge automation. He breaks down the technology beh…

Brought to You By:•⁠ Statsig ⁠ — ⁠ The unified platform for flags, analytics, experiments, and more. AI-accelerated development isn’t just about shipping faster: it’s abo…

David Kirtley is a nuclear fusion engineer and CEO of Helion Energy, a company working on building the world’s first commercial fusion power plant by 2028. Thank yo…

There are so many updates this week you might need two cups of coffee! Simon and Jillian guide your way.